Author:
Title:
Cembranoides 2,11-ciclizados del Caribe Mesoamericano : origen, estructura y actividad biológica
Classification:
RCQF20101902b
Summary:
Los cembranoides 2,11-ciclizados son una familia de diterpenoides altamente funcionalizados aislados mayoritariamente de octocorales del mar caribe. Biogenéticamente se proponen como derivados de la ciclación de la molécula del cembrano, con posteriores ciclaciones oxidativas que originan el esqueleto carbonado de asbestinino, briarellina, eunicelina y sarcodictina. 69 cembranoides 2,11-ciclizados se han aislado hasta diciembre de 2009 de tres gorgonios del caribe mesoamericano: 39 asbestininos, 22 Briarellinas, 7 sarcodictinas y una Eunicelina, de los cuales 44 son de Briareum asbestinum, 18 de Briareum polyanthes y 7 de Erithropodium caribaeroum. El origen biosintético, estructura y actividad biológica de estos 69 cembranoides se describen en este artículo. --
ABSTRACT: 2,11-cyclized cembranoids are a family of highly functionalized diterpenoids isolated mainly from Caribbean Sea octocorals. The proposed biosynthetic pathway arose from the 2,11-cyclization of the cembrane ring skeleton and further oxidative cyclizations and methyl migrations to construct the carbon skeleton of asbestinin, briarellin, eunicellin and sarcodictyin type compounds. Sixty nine cembranoids, thirty nine asbestinins, twenty two briarellins, seven sarcodictyins and one eunicellin have been isolated to December 2009 from three Caribbean gorgonian, forty four from Briareum asbestinum, eighteen from Briareum polyanthes and seven from Erithropodium caribbaeorum. An overview of thier biogenetic pathway, structure and biological activity are described in this paper. --
ABSTRACT: 2,11-cyclized cembranoids are a family of highly functionalized diterpenoids isolated mainly from Caribbean Sea octocorals. The proposed biosynthetic pathway arose from the 2,11-cyclization of the cembrane ring skeleton and further oxidative cyclizations and methyl migrations to construct the carbon skeleton of asbestinin, briarellin, eunicellin and sarcodictyin type compounds. Sixty nine cembranoids, thirty nine asbestinins, twenty two briarellins, seven sarcodictyins and one eunicellin have been isolated to December 2009 from three Caribbean gorgonian, forty four from Briareum asbestinum, eighteen from Briareum polyanthes and seven from Erithropodium caribbaeorum. An overview of thier biogenetic pathway, structure and biological activity are described in this paper. --
Original document:
En: Revista Científica de la Facultad de Ciencias Químicas y Farmacia y del Instituto de Investigaciones Químicas y Biológicas de la USAC ; (Vol.19, No.2) p.16-32 -- Guatemala : USAC, 2011. 2070-8246.
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